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PUBMED: Clinical Features and Short-Term Outcomes of 221 Patients With COVID-19 in Wuhan, China

J Clin Virol. 2020 Jun;127:104364.doi: 10.1016/j.jcv.2020.104364. Epub 2020 Apr 9.

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Free PMC article

Abstract

Background: In late December 2019, an outbreak of acute respiratory illness, coronavirus disease 2019 (COVID-19), emerged in Wuhan, China. We aimed to study the epidemiology, clinical features and short-term outcomes of patients with COVID-19 in Wuhan, China.

Methods: We performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia at a university hospital, including 55 severe patients and 166 non-severe patients, from January 2, 2020 to February 10, 2020.

Results: Of the 221 patients with COVID-19, the median age was 55.0 years and 48.9% were male and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia patients, the median age of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever, anorexia and dyspnea. On admission, 33.0% patients showed leukopenia and 73.8% showed lymphopenia. In addition, the severe patients suffered a higher rate of co-infections with bacteria or fungus and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU (intensive care unit) care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%.

Conclusions: Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes.

Conflict of interest statement

Declaration of Competing Interest The authors declared that they have no conflicts of interest.

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LINK: https://pubmed.ncbi.nlm.nih.gov/32311650/

References

    1. Lu H., Stratton C.W., Tang Y.W. Outbreak of Pneumonia of Unknown Etiology in Wuhan China: the Mystery and the Miracle. Journal of Medical Virology. 2020;92(Apr (4)):401–402. doi: 10.1002/jmv.25678. – DOI PMC PubMed
    1. Centers for Disease Control and Prevention (CDC): Coronavirus Disease . 2019. (COVID-19) Situation Summary.https://wwwcdcgov/coronavirus/2019-ncov/summaryhtml
    1. Zhu N., Zhang D., Wang W. A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine. 2020;382(Feb (8)):727–733. doi: 10.1056/NEJMoa2001017. – DOI PMC PubMed
    1. Lu R., Zhao X., Li J. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020;395(Feb (10224)):565–574. doi: 10.1016/S0140-6736(20)30251-8. – DOI PMC PubMed
    1. Chen N., Zhou M., Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(Feb (10223)):507–513. doi: 10.1016/S0140-6736(20)30211-7. – DOI PMC PubMed

Publication types

Source/Citations:

Zhang G, Hu C, Luo L, et al. Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. J Clin Virol. 2020;127:104364. doi:10.1016/j.jcv.2020.104364

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