DPC JOURNAL | Top Stories, DPC Perspectives & Latest Interviews

(PubMed) Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

2020 Jul 1;100(3):1065-1075.

doi: 10.1152/physrev.00013.2020. Epub 2020 Mar 27.

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

Ji HL, Zhao R, Matalon S, Matthay MA. Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. Physiol Rev. 2020;100(3):1065-1075. doi:10.1152/physrev.00013.2020
Affiliations

Free PMC article

Abstract

Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.

Keywords: COVID-19; SARS-CoV-2; comorbidity; fibrinolysis; plasmin(ogen).

Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

CLICK HERE …

SOURCE: https://pubmed.ncbi.nlm.nih.gov/32216698/; Ji HL, Zhao R, Matalon S, Matthay MA. Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. Physiol Rev. 2020;100(3):1065-1075. doi:10.1152/physrev.00013.2020

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: