DPC News

PUBMED | Costs and effectiveness of genomic testing in the management of colorectal cancer.

“The [Whole Genome] data, however, should be owned by the patient. Their Physician can help direct them on how to apply the information contained in WGS to maximize its benefits,” states Michael Tetreault, Editor of Concierge Medicine Today. “Patients need the ability to securely store, use, and understand genetic data.” Concierge Medicine Today advises this should be accomplished through physician involvement and technology that integrates genetic data into software applications [apps]. Software apps are now available that analyze genetic data and transform the data into actionable information that can have a real impact on health.

Oncology (Williston Park). 2015 Mar;29(3):175-83.

Costs and effectiveness of genomic testing in the management of colorectal cancer.


Numerous genomic tests are available for use in colorectal cancer, with a widely variable evidence base for their effectiveness and cost-effectiveness. In this review, we highlight many of these tests, with a focus on their proposed role, the evidence base to support that role, and the associated costs and risks. The tests with the strongest evidence base are KRAS genetic testing in the metastatic setting and microsatellite instability testing in selected patients and in stage II disease. There also may be a role for delineating recurrence-risk signatures for selected patients with stage II disease. The evidence to support broad utilization of uridine 5′-diphospho-glucuronosyltransferase 1A1 (UGT1A1) and dihydropyrimidine dehydrogenase (DPD) testing to guide irinotecan and fluorouracil dosing remains limited. There is much anticipation that next-generation sequencing will herald a new era of targeted therapy for patients with colorectal cancer; however, currently there are no data to support the introduction of widespread testing.


SOURCE: https://www.ncbi.nlm.nih.gov/pubmed/25783977


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